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2 edition of effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells found in the catalog.

effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells

Tanya Hodgins

effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells

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Published by Laurentian University in Sudbury, Ont .
Written in English


Edition Notes

StatementTanya Hodgins.
The Physical Object
Pagination36 l. :
Number of Pages36
ID Numbers
Open LibraryOL22161043M


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effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells by Tanya Hodgins Download PDF EPUB FB2

Introduction. Breast cancer is currently one of the most prevalent neoplasia, and around one in 10 Western women will develop breast cancer at some time in their life [].It is the second most common cause of cancer death in women, and despite radical mastectomy approximately one third of affected women by:   Consequently, MCF-7/Adr cells were more sensitive to the oxidative stress induced by bleomycin and menadione than MCF-7 cells.

In conclusion, our results suggest that regulating sulfur amino acid metabolism may be a possible Cited by: Enzymes involved in sulfur amino acid metabolism have been investigated as targets for anticancer drugs.

DNA methylation is an important control point effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells book gene expression, and the DNA methyltransferase inhibitor 5-azacytidine is FDA-approved for treating myelodysplastic syndrome (Stresemann et al., ).However, only part of the DNA methylation profile has been reported Cited by: Sulfur amino acid metabolism in doxorubicin-resistant breast cancer cells Article in Toxicology and Applied Pharmacology (1) June with 12 Reads How we measure 'reads'.

Request PDF | Multidrug Resistance Phenotype and Paclitaxel (Taxol®) Sensitivity in Human Renal Carcinoma Cell Lines of Different Histologic Types | We compared the effects.

Breast cancer (MCF-7/ADR cells) Targeted nuclear delivery of DOX; tumor penetration by breaking down the diffusion barriers caused by interstitial fluid pressure: Near-complete tumor growth arrest in MCF-7/ADR tumor-bearing mice compared with vehicle, free DOX, or DOX-loaded PLGA NPs [email protected] NPs: Lung cancer (ALuc cells)Cited by: 5.

Both nanoformulations showed cytotoxicity comparable to that of the commercial formulation and free PTX against human breast cancer cell line, MCF-7, however, higher anticancer activity against MDR cancer cell line, MCF-7/ADR, compared to the free PTX delivered in dimethyl sulfoxide, indicates that both SLNPs and NLCs would be effective Cited by: 3.

Breast cancer resistance protein (BCRP), an ATP-binding cassette (ABC) half transporter encoded by the Abcg2 gene, is reported to influence the pharmacokinetics of substrate drugs during clinical therapy. The aim of this study was to clarify the mechanisms that regulate the transcription of the chicken Abcg2 gene through effects of dimethyl sulfoxide on the energy metabolism of MCF-7-ADR breast carcinoma cells book and characterization of its promoter.

P-glycoprotein (P-gp) serves as a therapeutic target for the development of multidrug resistance reversal agents. In this study, we synthesized 21 novel compounds by peptide coupling at corresponding carboxyl and amino termini of (S)-valine-based bis-thiazole and monothiazole derivatives with diverse chemical scaffolds.

Using calcein-AM efflux assay, we identified Cited by: If the address matches an existing account you will receive an email with instructions to retrieve your username. Targeted Delivery of Doxorubicin by Folic Acid-Decorated Dual Functional NanocarrierCited by: Full text of "Annual report: National Cancer Institute (U.S.)" See other formats.

For this thesis, these samples were screened for in vitro cytotoxic activity against the drug-sensitive breast tumor cell lines MCF-7, TD, ZR and MDA-MB; the multidrug-resistant and P-glycoprotein (Pgp)-positive breast tumorcell lines MCF-7 Adr and MDA-A1r; and normal and malignant human breast epithelial cells (HBEC) in primary.

Plastoquinon-8 (Fig. ) commonly used in cell signaling, fuel and energy storage, fuel or energy source, and membrane integrity/stability.

Isolation of Plastoqublolle-8 Lipid (6 g, extracted by our routine procedure) from leaves of A. hippocastanum (equivalent to 53 g dry wt.; collected locally in July ) was chromatographed on a.

Full text of "Medicinal Chemistry of Bioactive Natural Products" See other formats. Greenhalgh, D.A. and Parish, J.H. () Effects of 5-fluorouracil on cytotoxicity and RNA metabolism in human colonic carcinoma cells. Cancer Chemother Pharmacol, 25, 37– Herrick, D. and Kufe, D.W. () Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA.

Out of 14 cases of non-small cell lung cancer, squamous cell carcinoma was found in 7 patients, giant cell carcinoma in 3, adenocarcinoma in 2, and 1 case of pleomorphic and mucoepidermoid carcinoma. Expression of cyclin D1 was not found, while expression of HER-2 and bcl-2 protein was established in one cases each.

p53 expression was noted in. Caspase-3 [x] Apoptosis Bcl-2 Bax Oxidative stress Caspase-9 Caspase-8 Survivin Mitochondria Neuroprotection Akt p53 TUNEL Breast cancer Cytotoxicity Year Published Plasmid transfer experiment including plasmid transformation and bacterial conjugation into the plasmidless competent cells of E.

coli MM (Rif r), as the recipients strain at a frequency 5x 10 -3 andx10 -4 respectively, appeared that transformed E. coli cells acquired all antibiotic resistances but lincomycin and pyocyanin production.

The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of.

Exhibitors of the 39th Annual Meeting & Exposition of CRS The following descriptions, supplied by the exhibiting companies as ofprovide product, service, and contact information.

The present invention relates to diarylheptanoid compounds and compositions comprising a diarylheptanoid compound. The present invention also relates to. Proc. of 21 st International Symposium Control of Energy, Industrial and Ecological Systems, Bankia, Bulgaria, November, ISSN Ribagin S., V.

Andonov, V. Chakarov. Possible Applications of Generalized Nets with Characteristics of the Places. The present invention relates to kinase polypeptides, nucleotides sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment jof various kinase-related diseases and conditions.

Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's predicted. molecular mechanism of pe5-induced cytotoxicity and generation of new cytotoxic nuclear-directed. The compound showed signicant cytotoxicity in P and L lymphocytic leukemia cells, as well as A human lung carcinoma cells, and marginal cytotoxicity in KB and human colon (HCT-8) and mammary (MCF7) tumor cells Kuei Chiu (Podophyllum emodi, Berberidaceae) Podophyllum emodi is found in western China and grows in most of the 5/5(2).

Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids. PubMed Central. Novaes, Júlia T. Temporal morphologic changes in human colorectal carcinomas following xenografting.

PubMed. Barkla, D H; Tutton, P J. The temporal morphologic changes of human colorec. Introduction. Chondrosarcoma is a malignant cartilage-forming tumor which accounts for ~20% of bone malignancies ().The conventional chondrosarcoma is associated with a significant rate of morbidity and the year survival rate is low (29–83%) (1,2).In addition to surgical resection which is the primary treatment option for patients with chondrosarcoma, conventional Cited by: Informa Healthcare USA, Inc.

52 Vanderbilt Avenue New York, NY # by Informa Healthcare USA, Inc. Informa Healthcare is an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number (Hardcover.

Oxidative Stress in Cancer Biology and Therapy Glycolysis plays an important role as a source of electrons for energy metabolism in cells under normal steady-state conditions. However, glucose metabolism also plays a major role in the detoxification of hydroperoxides produced as byproducts of O2 metabolism [8–12].

-induced c-Jun. In contrast, in MCFADR resistant breast cancer cells, quercetin was able to restore sensitivity to adriamycin and inhibit rhodamine efflux Interestingly, in mouse brain capillary endothelial cells (MBEC4), quercetin and kaempferol exhibited biphasic effects by activating P-gp at a low concentration (10 M) and inhibiting P-gp at a.